24-Hour Urine Creatinine Clearance Calculator

Calculate measured creatinine clearance (CrCl) using urine creatinine, serum creatinine, collected urine volume and collection duration. Optional tools estimate BSA-adjusted clearance and examine urine collection plausibility.

Calculate 24-Hour Urine Creatinine Clearance

Advanced options: age, sex, weight & height (optional)

Add age and sex for reference-interval context; weight for weight-normalized creatinine excretion; height and weight for BSA-adjusted CrCl. Reference comparisons are intended for adults.

Manual calculation is the default. Automatic updates occur only with valid values and will not scroll the page.

Collection quality matters: missing urine or inaccurate timing can substantially change measured CrCl.

Sensing Medicine — Timed Urine Creatinine Clearance Result
Measured creatinine clearance—mL/min (not BSA-indexed)
Urine flow rate—mL/min

Show calculation, input summary and clinical notes

Clinical caution: Timed urinary CrCl can overestimate true GFR because of tubular secretion and is vulnerable to collection error. Do not use this number alone for CKD diagnosis, staging or medication decisions.

For education and clinical decision support; not a substitute for laboratory-specific interpretation or professional judgment.

Normal 24-Hour Creatinine Clearance Reference Ranges

These are general, commonly published adult values, not universal ranges for unindexed timed urinary CrCl. Laboratories may report BSA-standardized results, and their own reference intervals should take precedence.

PopulationGeneral CrCl valuesImportant limitation
Adult males97–137 mL/minConfirm laboratory indexing and age applicability
Adult females88–128 mL/minConfirm laboratory indexing and age applicability
Older adultsNo universal single rangeClearance generally declines with age; do not apply an automatic per-decade correction

Source: MedlinePlus — Creatinine clearance test. The numerical ranges above should not be used to classify an individual's unindexed CrCl as normal or abnormal without matching laboratory context.

BSA-indexed creatinine clearance

When height and weight are provided, the calculator reports an additional BSA-indexed result in mL/min/1.73 m². No universal age- and sex-specific BSA-indexed reference table is applied: compare with the reference interval reported by the laboratory, using the same indexing convention. BSA-indexed creatinine clearance is not the same measurement as eGFR.

Expected 24-hour urinary creatinine excretion

PopulationGeneral weight-normalized reference values
Adult males14–26 mg/kg/24 h
Adult females11–20 mg/kg/24 h

Source: MedlinePlus — Creatinine urine test (U.S. National Library of Medicine). MedlinePlus also gives a broad overall value of 500–2000 mg/day, which varies with age and lean body mass. These ranges do not establish urine-collection completeness.

How Does the 24-Hour Urine Creatinine Clearance Calculator Work?

Measured creatinine clearance uses urine creatinine concentration, urine volume per minute and serum creatinine concentration from a corresponding collection period:

CrCl (mL/min) = [Urine creatinine × (Urine volume ÷ collection time in minutes)] ÷ Serum creatinine.

Urine and serum creatinine must first be converted to the same concentration units. Urine creatinine may be entered in mg/dL, mg/L (divide by 10 to obtain mg/dL), or mmol/L; serum creatinine may be entered in mg/dL or µmol/L.

Worked Example

Urine creatinine = 100 mg/dL; serum creatinine = 1.0 mg/dL; total urine volume = 1500 mL; collection duration = 24 hours. Urine flow = 1500 ÷ 1440 = 1.0417 mL/min. Therefore, CrCl = 100 × 1.0417 ÷ 1.0 = 104.2 mL/min (unindexed). Select “Load Example” above to reproduce it.

Measured CrCl vs Cockcroft–Gault vs eGFR

MethodUrine collection?What it reports
Timed urine CrClYesMeasured urinary creatinine clearance (mL/min); optional BSA indexing
Cockcroft–GaultNoEstimated creatinine clearance based on serum creatinine and patient characteristics
eGFRNoEstimated glomerular filtration rate, typically mL/min/1.73 m²

Measured CrCl is not interchangeable with a reference-method measured GFR or CKD-EPI eGFR. For more about body-size adjustment, see our BSA Calculator and guide to body surface area.

Collection adequacy and limitations

The optional age, sex and weight inputs help contextualize daily urinary creatinine excretion. A value outside a broad reference interval may prompt review of collection timing, missed voids, weight and body composition; a value within the interval does not prove completeness. Frailty, sarcopenia, diet, unusual muscle mass and kidney dysfunction can influence excretion.

  • Incomplete or excessive urine collection may bias clearance.
  • Creatinine tubular secretion means CrCl may exceed true GFR.
  • Rapid changes in kidney function can invalidate steady-state assumptions.
  • BSA-indexed and unindexed clearance have different units and clinical uses.
  • CKD staging requires appropriate GFR assessment, albuminuria and chronicity; do not infer a CKD G-stage from urine CrCl alone.

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References

  1. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int. 2024 Apr;105(4S):S117-S314. doi:10.1016/j.kint.2023.10.018. PMID:38490803.
  2. Ix JH, Wassel CL, Stevens LA, Beck GJ, Froissart M, Navis G, Rodby R, Torres VE, Zhang YL, Greene T, Levey AS. Equations to estimate creatinine excretion rate: the CKD epidemiology collaboration. Clin J Am Soc Nephrol. 2011 Jan;6(1):184-91. doi:10.2215/CJN.05030610. PMID:20966119; PMCID:PMC3022241.
  3. Shemesh O, Golbetz H, Kriss JP, Myers BD. Limitations of creatinine as a filtration marker in glomerulopathic patients. Kidney Int. 1985 Nov;28(5):830-8. doi:10.1038/ki.1985.205. PMID:2418254.
  4. Mosteller RD. Simplified calculation of body-surface area. N Engl J Med. 1987 Oct 22;317(17):1098. doi:10.1056/NEJM198710223171717. PMID:3657876.
  5. Shahbaz H, Rout P, Gupta M. Creatinine Clearance. [Updated 2024 Jul 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK544228/
  6. MedlinePlus [Internet]. Bethesda (MD): National Library of Medicine (US); Creatinine clearance test [updated 2025 Jul 1; cited 2026 Oct 19]; [about 3 screens]. Available from: https://medlineplus.gov/ency/article/003611.htm
  7. MedlinePlus [Internet]. Bethesda (MD): National Library of Medicine (US); Creatinine urine test [updated 2025 Jul 1; cited 2026 Oct 19]; [about 3 screens]. Available from: https://medlineplus.gov/ency/article/003610.htm
Author details

Written by: Dr. S S Asthana, MBBS, MD. ORCID: 0000-0001-9459-8354.

Medical disclaimer: This educational tool is not a diagnosis, CKD staging instrument or substitute for clinical evaluation. Disclaimer · Terms · Privacy

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